The Ultimate Guide to Why I am not losing Weight on Wegovy?



February 2, 2024

Ever feel like you’re playing a game of hide-and-seek with your weight loss goals while on Wegovy?

Let’s unravel this mystery together.



Why am I not losing weight on Semaglutide?


Why am I not losing weight on Wegovy?

Why am I not losing weight on Ozempic?

Why am I not losing weight on Semaglutide?

These 3 questions will be answered because they are the same product. Semaglutide is the compound that makes up Ozempic, which is the medication for people diagnosed with diabetes, and Wegovy, which is the weight loss medication of semaglutide.


How does Semaglutide work?

  • Decreases sugar release from the liver.
  • Suppresses appetite.
  • Delayed gastric emptying.
  • Increase insulin secretion.
  • Cardioprotective
  • Muscles increase sugar usage.



Understanding weight loss from Wegovy studies.


DosagePercent (%) body weight % achieving at least 5% reduction in BW% achieving at least 10% reduction in BW% achieving at least 15% reduction in BW
2.4 mg semaglutide14.9%86.4%69.1%50.5%
placebo 2.4% 31.5%12.0%4.9%

This is a table from the Step 1 trial for semaglutide (Wegovy) showing weight loss of the highest dose of medication.  At the highest dose, 13.5% of people only lose 5% or less than in body weight.  This means out of 100 people on semaglutide, 13-14 people lost less than 5% of their body weight. 

There is such a thing as non-responders to this medication.   

Body weight measured on the scale is not the only that this medication affects.  You may not lose pounds on a scale, but you may lose inches.  Losing inches, especially around the midsection or reducing visceral fat, is a more significant indicator of favorable health outcomes than just what the scale says.




20 Answers to “Why am I not losing weight on Wegovy?”

  1. Are you being consistent?  Are you consistently taking the medication as prescribed?  Are you skipping doses?
  2. Are you being mindful of what you are eating?  You can outeat any weight loss medication or diet.  It is essential to make lifestyle changes.
  3. Are you losing inches? – The bathroom scale may not reflect the positive changes that the body is making.
  4. Are you getting enough protein? If you are in a calorie and protein deficit, you may be losing fat but also muscle. Maintaining and possibly gaining muscle mass is crucial for long-term weight loss success.
  5. Are you choosing healthy foods? You can outeat any weight loss medication with high-calorie, high-fat foods
  6. Are you eating enough calories? If you eat too few calories, your body may adjust, making weight loss more difficult.
  7. Are you on the correct dose- The medication is titrated up to the proper dose for you
  8. Are you injecting properly? Be sure you are correctly injecting the medication.
  9. Are you varying injection sites?- Some injection sites may work for you better than others. Also, are you rotating sites for each weekly injection?
  10. Are you drinking water?- Being adequately hydrated is important for weight loss.
  11. Are you strength training?- Incorporating weights regularly is crucial to building metabolically active tissues like our muscles.
  12. Are you getting enough sleep? Sleep plays a huge role in everything from mood to food choices. Not getting enough sleep can negatively affect weight loss.
  13. Is regular physical activity a part of your day? Regular movement, getting up from your desk and moving around, is essential for weight loss.
  14. Are you irregularly taking medication? Are you having an issue getting your dose? Do you have to switch doses due to supply chain issues?
  15. Is your formula compounded? Compound formulas may vary from pharmacy to pharmacy.
  16. Are your goals realistic? According to the Step 1 study, 50% of the people lost 15% of their body weight on the highest dose of Wegovy. Have you reached your 15%?
  17. Are you consuming liquid calories? Liquid calories are utilized quicker than solid calories, which can make weight loss more difficult,
  18. Are you constipated- Constipation can be a side effect of this medication, and it may seem like you are not losing weight, but constipation may be the cause.
  19. How do you manage stress? Stress can be multifactorial. High levels of stress hormones can inhibit weight loss. Another factor is what you do to manage stress. Many people can be stress eaters. A good question to answer is, “How do you manage stress?’
  20. Are you having side effects? There are side effects to this medication, and they could be affecting your weight loss.


Why am I not losing weight on Ozempic?


The exact reasons why someone may not be losing weight on Wegovy are the same reasons why someone may not be losing weight on Ozempic.


Is it normal to not lose weight on Wegovy?


Not everyone will react to this medication the same. Not everyone will lost weight on this medication. There will be varying degrees of weight loss for different people. These are some ideas to help you with your weight loss journey.

A person with socks standing on a scale.
Senior Couple In Fitness Clothing Running Along Beach



Does semaglutide work for everyone?


The answer is no. Semaglutide does not work for everyone. Everyone on semaglutide may lose a different amount of weight. Some people will lose more than 15% of their body weight and those who may lose less than 5% of their body weight.

Inbody 770 Scale


If you are looking for a scale that helps determine if you are losing weight, body fat, muscle mass, or visceral fat, check out the Inbody 770 scale.  It is a fantastic scale that helps answer the “Why am I not losing weight questions.”


Find a dietitian for help managing your Wegovy weight loss concerns.


A dietitian may help you uncover why you are not having more success with your weight loss goals. I can calculate your estimated needs, customize a meal plan, and help strategize your plan for weight loss success.  Also, most importantly, set realistic expectations and goals.

 You may be pleasantly surprised that a dietitian is covered by insurance covers your visit.  

The Skinny on Wegovy diet and exercise.


A key point for success with any lifestyle change, whether medication is used as a tool or not, is consistency.  It is the same for Wegovy.  Implementing Wegovy with diet and exercise can be the key to your long-term weight loss success.

Healthy foods for Mounjaro

Final Thoughts.


There are many factors, not just personal failure that could be the reason why you are not losing weight on Wegovy.