Mounjaro: Foods to Avoid

February 9, 2024



Exploring the best diet while on Mounjaro (tirzipatide) is important for not only successful weight loss, blood sugar management but also to reduce or eliminate the side effects from this medication. This offers practical advice on managing medications, while adhering to the recommended dietary guidelines for a healthy and sustainable weight loss. Let’s learn what foods not to eat and find what your best diet while taking Mounjaro.

What is Mounjaro?


Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist.

It works by targeting multiple pathways involved in blood sugar regulation.

  • including stimulating insulin release in response to elevated blood sugar levels,
  • slows gastric emptying.
  • regulate the rate of glucose absorption after meals,
  • This mechanism is what potentially impacts appetite and body weight regulation.
Medications and syringe for medication.



The Role of Diet in Mounjaro Treatment- SO IMPORTANT

Why should you avoid these foods with Mounjaro?

  1. Managing your blood sugar is important. Foods that are high in simple carbohydrates or sugars may negatively affect your blood sugar. Eating a balanced diet with complex carbohydrates, lean proteins and healthy fats are key to maintaining blood sugar balance.
  2. Diabetes can also be hard on your heart and eating a diet that benefits your lipids is also key for long term success. One tool that is used as an indicator of heart health is your lipid profile which includes cholesterol, LDL cholesterol, triglycerides and HDL cholesterol.
  3. These medications may have negative GI side effects and may upset your stomach. One of the unfortunate side effects from this medicine is GI upset, bloating, diarrhea, constipation, gas nausea and these foods seem to trigger more than others.
  4. One of the side effects of this Mounjaro is loss of appetite. It is really important that the foods you eat have some nutritional value, whether it is a source of protein, fiber, vitamins, minerals or antioxidants. It is important to eat a well-balanced diet to prevent nutritional deficiencies.

10 Foods to Avoid with Mounjaro

Here is a list of foods to avoid on Mounjaro because they may cause GI upset, impact cholesterol levels, cause blood sugar spikes or are not beneficial for weight loss.

  1. Large portions- Be mindful of the amount of food you eat. You may be used to a certain amount of food filling you up, but this may not be the case once taking Mounjaro. Take smaller portions and don’t be afraid of leaving some on your plate.
  2. High fat food- Food high in fat such as cheese, certain meats, bacon, ice creams, desserts may take longer to digest, and you may feel uncomfortable or other GI issues. They may also interfere with your weight loss goal and elevate your cholesterol and LDL levels.
  3. Fried foods- Fried foods are high in fat and calories, they may take longer to digest than foods not fried. Fried foods are also high in unhealthy fats.
  4. Rice- Rice has a high glycemic index. If rice is on the menu, be mindful of portion sizes (⅓ of a cup) and pair with a source of protein. Rice, although delicious and versatile does not have much nutrition benefit other than a great source of carbohydrates.
  5. Highly processed foods- such as crackers, chips, cookies, certain cereals, breads. These foods can contain empty calories and not much nutrition value. They can raise your blood sugar, inhibit weight loss and also negatively affect you triglyceride levels.
  6. Foods high in sugar. Food such as desserts, candies, and high fructose corn syrup should be avoided. It can make weight loss more difficult and does not offer any nutritional value except
  7. Soda/carbonated beverages- Soda causes the stomach or intestine to bloat due to the carbonation. It is recommended to limit carbonated beverages or soda due to its effect on GI tracts and also contains no nutritional value.
  8. Sugary drinks- Contain added sugar which can spike your blood sugar and also can prevent weight loss.
  9. High acid foods- Foods that trigger reflux or GERD can be worse when taking these medications. Foods that can trigger reflux are tomatoes, spicy foods.
  10. Foods that do not help with constipation-  Less than 5% of people complain of GI side effects on Mounjaro.  One of the main side effects that can be contributed to diet is constipation which can be significant.  There are remedies for constipation on Mounjaro.

Best Diet While Taking Mounjaro.

Finding out what not to eat on Mounjaro can be difficult. A registered dietitian may be helpful to guide you to your best self. Your insurance may cover a dietitian especially if diabetes or obesity or the reason you are interested or started this medication.  

Why am I not losing weight on weight loss medications?

If you feel that you are not losing weight on weight loss medications. There are many reasons, uncover some of the reasons why you are not losing weight on weight loss medication. There is also the Inbody 770 scale that can measure your weight, visceral fat, water weight, and muscle mass.