The Complete Guide to Why You Are Not Losing Weight on Mounjaro.



March 11, 2024

Everybody is losing weight on Mounjaro (tirzepatide).

A can’t fail medication, right?

You are not losing weight on Mounjaro. Are you the only one?

Or your weight loss on Mounjaro (tirzepatide) has stalled.

You are not alone, there is help.

Let’s find out the answer to your burning question.



Why am I not losing weight on Mounjaro (tirzepatide)?


Why am I not losing weight on Mounjaro?

Why am I not losing weight on Zepbound?

Why am I not losing weight on tirzepatide?

These 3 questions will be answered because they are the same product.  Tirzepatide is the compound that makes up Mounjaro, which is the medication for people diagnosed with diabetes, and Zepbound, which is the weight loss medication of tirzepatide.


How does tirzepatide work?

  • Decreases sugar release from the liver
  • Suppresses appetite
  • Delayed gastric emptying
  • Increase insulin secretion
  • Cardioprotective
  • Muscles increase sugar usage.

I am not losing weight on Mounjaro (tirzepatide) but losing inches?


Body weight measured on the scale is not the only that this medication affects. Losing inches, especially around the midsection or reducing visceral fat, is a more significant indicator of favorable health outcomes than just what the scale says.

One key point is to start looking for Non-Scale victories which are also important health markers than just our weight.

“Why am I not losing weight on Mounjaro?”


Are you ready for this?

  1. You may be a non-responder (Yikes!) Not everyone lost more than 5% of their body weight on Mounjaro. Some studies done by Lilly say that more than 80% lost 5% of their body weight. That means 19% lost 5% or less
  2. You may be a diabetic or have insulin resistance. People with insulin resistance or diabetes have a much harder time than losing weight with or without medication.
  3. People that had intensive diet and lifestyle interventions had the most success in weight loss percentage. Are you participating in an intense diet and lifestyle modification? That can be difficult without support.
  4. Are you losing inches on Mounjaro/Zepbound (tirzepatide)?- The bathroom scale may not reflect the positive changes that the body is making.  Look at non-scale victories.
  5. Are you getting enough protein? If you are in a calorie and protein deficit, you may be losing fat but also muscle. Maintaining and possibly gaining muscle mass is crucial for long-term weight loss success.
  6. Are you choosing healthy foods? You can out eat any weight loss medication with high-calorie, high-fat foods.
  7. Are you eating enough calories? If you eat too few calories, your body may adjust, making weight loss more difficult.
  8. Are you on the correct dose- Is the medication is titrated up to the proper dose for you?
  9. Are you injecting properly? Be sure you are correctly injecting the medication.
  10. Are you varying injection sites?- Some injection sites may work for you better than others. Also, are you rotating sites for each weekly injection?
  11. Are you drinking water? – Being adequately hydrated is important for weight loss.
  12. Are you strength training?- Incorporating weights regularly is crucial to building metabolically active tissues like our muscles.
  13. Are you getting enough sleep? Sleep plays a huge role in everything from mood to food choices. Not getting enough sleep can negatively affect weight loss.
  14. Is regular physical activity a part of your day? Regular movement, getting up from your desk, and moving around, is essential for sustained weight loss.
  15. Are you irregularly taking medication? Are you having an issue getting your dose? Do you have to switch doses due to supply chain issues?
  16. Is your formula compounded? Compound formulas may vary from pharmacy to pharmacy.
  17. Are your goals realistic? Have you reached a certain percentage of weight loss? Some people may lose less than 5% of their body weight. There are people that lose 20-30% but that is not realistic for everyone that takes this medication.
  18. Are you consuming liquid calories? Liquid calories are utilized quicker than solid calories, which can make weight loss more difficult,
  19. Are you constipated- Constipation can be a side effect of this medication, and may seem like you are not losing weight, but constipation may be the cause.
  20. How do you manage stress? Stress can be multifactorial. High levels of stress hormones can inhibit weight loss. Another factor is what you do to manage stress. Many people can be stress eaters. A good question to answer is, “How do you manage stress?’
  21. Are you having side effects? There are side effects to this medication, and they could be affecting your weight loss.



What if I stopped Losing weight on Mounjaro?



If you have stopped losing weight on Mounjaro, reread the above list. Many key points can help restart weight loss with Mounjaro. Meeting with a registered dietitian can help pinpoint some issues you are struggling with and help with a resolution.




Why am I not losing weight on Mounjaro or Zepbound?


The exact reasons why someone may not be losing weight on Zepbound are the same reasons why someone may not be losing weight on Mounjaro,


Is it normal to not lose weight on Mounjaro?


It is possible to have no weight loss with Mounjaro.  It may work differently for everyone. You may lose inches but not weight on Mounjaro and that may be a positive effect of this medication.  Other benefits are not scale-related, such as better blood sugar control.

Can I Gain Weight on Mounjaro?


It is possible to gain weight on Mounjaro. Weight gain can be for a variety of reasons. If there is a sudden weight gain, it could be due to fluid shifts, constipation, or fluid retention. If weight gain on Mounjaro (tirzepatide) trends up, it may be related to diet and food intake. It may also be a result of increased muscle mass, which is a great thing! A great tool to help decipher weight changes in the Inbody 770 scale.

Mounjaro Diet:


A dietitian may help you uncover why you are not having more success with your weight loss goals. A dietitian can help with eating in Mounjaro and help with the best diet on Mounjaro. Although a dietitian cannot prescribe weight loss medication, they can help you maximize the benefits of this medication.

If you struggle to lose weight on Mounjaro, you may need a customized meal plan, calculation of your estimated carbohydrate, protein, and fat needs, and help strategize your plan for weight loss success. This can be your dietitian’s prescription!

Most importantly, set realistic expectations and goals.

You may be pleasantly surprised that your dietitian is covered by insurance.

You may be pleasantly surprised that your dietitian is covered by insurance.

Looking for a step by step guide for the best diet on Mounjaro?

This guide will help you manage any negative symptoms and help optimize blood sugars and maximize weight loss.

A person with socks standing on a scale.
Senior Couple In Fitness Clothing Running Along Beach



Does Mounjaro (tirzepatide) work for everyone?


The answer is no.  Tirzepatide does not work for everyone.  Everyone on tirzepatide may lose a different amount of weight.  Some people will lose more than 15% of their body weight and those who may lose less than 5%


Find a dietitian to help manage your Mounjaro weight loss concerns.


A dietitian may help you uncover why you are not having more success with your weight loss goals. I can calculate your estimated needs, customize a meal plan, and help strategize your plan for weight loss success.  Also, most importantly, set realistic expectations and goals.

 You may be pleasantly surprised that a dietitian is covered by insurance covers your visit.  

The Skinny on Mounjaro diet and exercise


Consistency is the key to success with any lifestyle change, whether medication is used as a tool or not. It is the same for Zepbound and Mounjaro. Implementing Zepbound with diet and exercise can be the key to long-term weight loss success.

Inbody 770 Scale


If you are looking for a scale that helps determine if you are losing weight, body fat, muscle mass, or visceral fat, check out the Inbody 770 scale.  It is a fantastic scale that helps answer the “Why am I not losing weight on Mounjaro” questions.

Healthy foods for Mounjaro

Final Thoughts.


There are many factors, not just personal failure, that could be the reason why you are not losing weight on Mounjaro (tirzepatide).